Although, the defined c-statistic or area under the ROC curve (AUC-ROC) of 0.9224 in our series indicates that the predictive value of BMI-1 autoantibody in cervical carcinoma is modest, cervical carcinoma heterogeneity showed similar limitations for other cervical carcinoma markers, such as CYFRA21.1, SCC and CEA, each varying somewhat with stage and histology [31], [32]. The gene discussed is SERPINB3; the disease is cervical carcinoma.