Current screening tests for fetal DS detection increases detection rate by integration of multiple methods, such as measurement of nuchal translucency and blood tests for numerous maternal serum markers, including alpha fetoprotein, unconjugated estriol, human chorionic gonadotrophin, and inhibin-A, but at a higher screen-positive rate (approximately 16–22%) [3], [4]. This evidence concerns the gene AFP and Dravet syndrome.