SPINK1 and chronic pancreatitis: It may be worthy of mentioning that a well-studied protease inhibitor, pancreatic secretory trypsin inhibitor (Serine protease inhibitor Kazal-type 1, SPINK1), whose gene mutation was frequently associated with chronic pancreatitis and pancreatic adenocarcinoma by a number of studies [51], [52], was not detected in any pancreatic tissue in our current investigation.