The TFSEARCH (http://www.cbrc.jp/research/db/TFSEARCH.html) database indicated that an A to G change in the rs2659056 increases scores for binding of the orphan nuclear receptor RORalpha, which has been shown to be involved in the control of cell growth and differentiation, along with the control of metastatic behavior of androgen-independent prostate cancer cells [29]. The gene discussed is ESRRB; the disease is Familial prostate cancer.