At the end of chemotherapeutic treatment (day 63 p.i.), WT (Fig. 4D) and Tm-TNF (Fig. 4F) mice had pulmonary pathology characterized by well-defined granulomas and clear alveoli whereas TNF−/− mice displayed higher inflammation characterized by peri-vascular and peri-bronchiolar inflammation (Fig. 4E). Here, TNF is linked to Granuloma.