Also, the interobserver agreement of the community-based pathologists for categorizing lesions as high-grade CIN versus CIN 1 or negative for dysplasia significantly improved with the addition of the p16INK4a -immunostained slides, with a κ coefficient of 0.749 (for H&E stained slides only, the κ coefficient was 0.566). Here, CDKN2A is linked to dysplasia.