MKI67 and cervical squamous intraepithelial neoplasia: Although Ki-67 has been used as a diagnostic adjunct for the classification of cervical tissue specimens [52, 53], the expression of Ki-67 alone does not discriminate HPV-mediated dysplasia versus benign proliferating cells in benign reactive processes, which limits its use in cytologic specimens as a specific marker of underlying CIN or glandular neoplasia.