We previously reported that upregulation of human SNAI1 (Snail) expression by reactive oxygen species contributes to the invasive nature of HCC, in part by inducing the expression of matrix metalloproteinases and downregulating E-cadherin expression through both transcriptional repression and epigenetic modification of the E-cadherin promoter [7]. Here, CDH1 is linked to hepatocellular carcinoma.