We used two commonly known glaucoma promoting agents, i.e.TGF-β2 and DEX to evaluate their effect on caveolins.TGF-β2 is known to be strongly upregulated in aqueous humor of POAG patients [41], whereas DEX is a glucocorticoid hormone which influences many aspects of cell physiology. The gene discussed is TGFB2; the disease is glaucoma.