After adjusting for the effect of the risk genotypes of the three LOXL1 SNPs and factors known to influence the prevalence of XFS, including sex, diabetes mellitus, hypertension, retinal vein occlusion, cardiovascular disease, and cerebrovascular disease, only rs1048661 among three SNPs remained significantly associated with disease risk (OR=12.13, 95% CI=4.11–35.78, p=6.113×10−6). The gene discussed is LOXL1; the disease is diabetes mellitus.