After adjusting for the effect of risk genotypes of the three LOXL1 SNPs and factors known to influence the prevalence of XFS, including sex, diabetes mellitus, hypertension, retinal vein occlusion, cardiovascular disease, and cerebrovascular disease, only rs1048661 among the three LOXL1 SNPs showed an independent association with XFS in the Korean population, suggesting that the other two SNPs are not independent, but are more likely to be genetic markers in LD with rs1048661. The gene discussed is LOXL1; the disease is cardiovascular disorder.