LOXL1 and open-angle glaucoma: While no significant differences in allele and genotype frequencies were found between the XFS subgroup and the XFG subgroup in cases, and among subgroups, including cataract, POAG, CACG, and secondary glaucoma in controls, significant differences in allele and genotype frequencies of the three LOXL1 SNPs were observed between entire cases and control subjects.