INS and colonic neoplasm: When the analysis was restricted to cases of colon cancer (N=65), HRs for the middle and highest tertiles vs the lowest tertile of glucose were 1.72 (95% CI: 0.85–3.48) and 2.25 (95% CI: 1.12–4.51), respectively, P for trend 0.02, whereas insulin and HOMA-IR were not associated with risk.