Autoimmune diseases such as Systemic Lupus Erythematosus (SLE) are the epitome of self versus non-self disarray, and knowing that FoxP3+ Treg cells are depleted during attacks and flares of lupus, supports the concept of VIP's potential as a drug for SLE and other autoimmune diseases and disorders with vasculitis. The gene discussed is FOXP3; the disease is autoimmune disease.