Furthermore, we examined the expression and distribution of cannabinoid receptors 1 and 2 and the AEA metabolizing enzymes, FAAH and the key enzyme involved in AEA synthesis, NAPE-PLD, in the placenta and decidua of women having a spontaneous miscarriage and those undergoing induced abortions with an anti-progestin (mifepristone; RU486) and a prostaglandin (misoprostol) in comparison to the expression levels in normal pregnancy. Here, CNR1 is linked to spontaneous abortion.