CDH1 and metastatic malignant neoplasm in the lymph nodes: The combination of E-cadherin-negative and Ki67-positive expression was revealed to be a more significant prognostic indicator than either E-cadherin or Ki67 expression alone by multivariate analyses (P = 0.004, OR = 2.784), while a univariate analysis revealed that the overall survival was significantly correlated with the E-cadherin expression, Ki67 expression, stage, tumor size and lymph node metastasis (Table 2).