[1]. One of these ‘pro-tumour’ factors, Vascular Endothelial Growth Factor (VEGF) is known for sustaining tumour growth via its angiogenic properties but can also elicit an inhibitory effect on DC differentiation and maturation, enhancing tumour survival [1], [5], [6], [7], [8]. VEGF has successfully been targeted by the humanised monoclonal antibody Bevacizumab (Avastin) [9], however response rates are approximately 40% and many patients develop resistance to this treatment. The gene discussed is VEGFA; the disease is neoplasm.