A recent study conducted by Li and co-workers however has demonstrated that partial depletion of Treg cells through PC61 does not alter tumor size within a murine inoculated with M04 melanoma, but that 95% ablation through the use of Foxp3-DTR transgenic animals results in complete regression of large established tumors and an associated increase in tumor-specific CD8+ T cell infiltration [28]. This evidence concerns the gene CD8A and neoplasm.