Our observations corroborate those of Hollestelle et al., [15] that circulating concentrations of both VWF and its propeptide are specifically and markedly raised in patients with P. falciparum infection, and that VWF and propeptide levels are markers of endothelial activation in falciparum malaria, at higher levels than seen in other infections, suggesting a specific perturbation in malaria. This evidence concerns the gene VWF and malaria.