VWF and lactic acidosis: There was no significant difference in median VWF or propeptide concentration between children with lactic acidosis (plasma lactate >5 nM) (VWF: 224.5 (63.4–378.4); propeptide: 26.4 (4.8–50.7) and those with plasma lactate <5 nM (VWF: 185.0 (40.5–484.3); propeptide: 28.4 (5.3–107.5) (p = 0.340 and p = 0.504 respectively).