In addition, we found that SNPs from several non-HLA genes including rs2251396, rs2523454 and rs12175589 in MICA, rs7770216 in LOC729816, rs511027 in NOTCH4, rs9257483 in OR12D2 and 9262167 in IER3 were associated with psoriasis in multiple regression analyses. The gene discussed is NOTCH4; the disease is psoriasis.