PPARG and diabetes mellitus: Consistent with this theory, the ongoing telmisartan alone and in combination with ramipril global endpoint trial (ONTARGET) [29] and the parallel telmisartan randomized assessment study in ACEI intolerant subjects with cardiovascular disease (TRANSCEND) trial [30] have reported the effects of telmisartan, a unique ARB with peroxisome proliferator-activated receptor-gamma (PPAR-gamma-) stimulating activity, and the ACEI ramipril on cognitive function in patients aged 55 years and older with established atherosclerotic cardiovascular disease or diabetes with end-organ damage.