Aside from its effects on hypertension [22–25], viral overexpression of ACE2 has shown reduced collagen production in cultured fibroblasts [106] as well as inhibition of Ang-II-induced fibrosis and hypertrophy in vivo [109], stabilisation of atherosclerotic plaques [110], and renoprotection [24]. This evidence concerns the gene ACE2 and hypertensive disorder.