To this end, we selected breast cancer cell lines with low endogenous expression of BMP4 (HCC1419, SK-BR-3), BMP7 (MDA-MB-231, T-47D) or both (HCC1954, MDA-MB-361, ZR-75-30) [12,14] and treated them with the corresponding BMP ligand (rhBMP4 or rhBMP7) and vehicle controls (Figure 1A). This evidence concerns the gene BMP7 and breast cancer.