On the contrary, out of the identified 15 proteins, α-amylases precursor, β-2 microglobulin, G3PDH, IGKC protein, E-FABP, carbonic anhydrase VI and SPLUNC-2 showed the most significant differences in the expression in comparison both to healthy volunteers and non-SS sicca syndrome and, therefore, appeared to be the most significant discriminatory biomarkers for SS. This evidence concerns the gene BPIFA2 and synovial sarcoma.