When pSS patients were compared to patients affected by non-SS sicca syndrome, α-amylases precursor, carbonic anhydrase VI, G3PDH and SPLUNC-2 were still significantly decreased in the former group, while, on the contrary E-FABP, β-2 microglobulin and IGKC protein showed a persistent, significant increase. The gene discussed is IGKC; the disease is Sjogren syndrome.