On the other hand, as expected, subjects with RA-sSS or SSc-sSS shared a number of salivary biomarkers, whereas subjects with sicca complaints but without SS were characterised by a proteomic profile much closer to that of healthy subjects with the exception of an increase of proteins related to inflammation (that is, S100 proteins) and a decrease of secretory proteins, such as PIP and SPLUNC-2. This evidence concerns the gene BPIFA2 and rheumatoid arthritis.