AKT1 and head and neck squamous cell carcinoma: In addition, treatment of HKs with LBH589 and BGT226 alone or LBH589 in combination with BGT226 or BKM120 had no effect on phospho-AKT levels (Figure 3C) and induced a small decrease in the viability of HKs (Figure 3D), HNSCC cells were much more sensitive to the cytocidal effects of these drugs alone or in combination (Figure 3D and Supplementary Figure 6).