Giallauria et al. [19] found 3-month exercise induced a reduction in NT-pro-BNP and an increase in E/A in patients with LV dysfunction after myocardial infarction, and they thought those changes might be secondary to a reduction of LV systolic stress or afterload leading to an increase in atrioventricular pressure gradient in early diastole. This evidence concerns the gene NPPB and myocardial infarction.