The concurrent suppression of a number of heat shock proteins, heat shock factor protein 1(HSF1), and known anti-inflammatory responses of the immune system, such as interleukin 1 receptor antagonist, and galectin-3-binding protein in oral epithelium of HIV chronically infected subjects, suggest that a sustained presence of HIV infection eventually leads the immune system into a state of immunological tolerance towards multiple antigens. The gene discussed is HSF1; the disease is HIV infectious disease.