Figure 5 illustrates the predicted effect of VKORC1 or CYP2C9 variant allele burden on responses of AF and VTE patients initiated with WRAPID nomogram (5A, 5B), Kovacs nomogram (5C, 5D), warfarindosing.org genetics (5E, 4F), and clinical nomogram (5G, 5H), respectively. The gene discussed is VKORC1; the disease is atrial fibrillation.