SOCS3 and serum lipopolysaccharide activity: When the mice were given rmMFG-E8 i.p., the SOCS3 expression in peritoneal cells and spleen was significantly induced, which become further elevated during endotoxemia by i.p. LPS injection, but comparatively decreased in levels if they were pre-treated with rmMFG-E8 followed by endotoxemia (Fig. 5C, 5D).