In support of our current in vitro findings, several in vivo studies have also been conducted to prove the beneficial roles of exogenous rmMFG-E8 in sepsis, colitis, gut, renal and hepatic ischemia and reperfusion injuries by downregulating not only the TNF-α levels but also other pro-inflammatory cytokines in target tissues and serum samples [4], [5], [31]. The gene discussed is TNF; the disease is colitis.