Overall, we found that the hOGG1 Ser326Cys polymorphism was significantly associated with the risk of cancer (Cys/Cys vs. Ser/Ser: OR = 1.19, 95%CI = 1.09–1.30, P<0.001; Cys/Cys vs. Cys/Ser+Ser/Ser: OR = 1.16, 95%CI = 1.08–1.26, P<0.001; Table S2, Figure S2). Here, OGG1 is linked to cancer.