We did not find that hOGG1 Ser326Cys polymorphism was significantly associated with cancer risk in Caucasian population and other cancer types including breast, prostate, pancreatic, bladder, gallbladder, gastric, colorectal, and esophageal cancer, suggesting the influence of the genetic variant may be masked by the presence of other as-yet unidentified causal genes involved in carcinogenesis. This evidence concerns the gene OGG1 and esophageal cancer.