When the data were analyzed in subgroups of subjects stratified by ethnicities, we found that the hOGG1 Ser326Cys polymorphism was significantly associated with overall cancer risk among Asians (Cys/Cys vs. Ser/Ser: OR = 1.21, 95%CI = 1.10–1.33, P<0.001; Table S2). The gene discussed is OGG1; the disease is cancer.