So far, there were so many reports about the association of hOGG1 Ser326Cys polymorphism with risk of different cancers, including breast [6]–[18], prostate [19]–[25], pancreatic [26], [27], bladder [28]–[34], gallbladder [35]–[38], gastric [39]–[49], colorectal [50]–[63], esophageal [64]–[68], lung [69]–[85], cervical cancers [86], [87], and so on [88]–[101]. This evidence concerns the gene OGG1 and cancer.