However at the very late stage of the infection (10 h p.i.)amphiphysin-1 was strongly relocalized to the plasma membrane and virus-induced filopodia/neurite structures (Figures 5D and S1B), thus differing from the pattern seen in HeLa cells where amphiphysin-2 remained associated with the replication complexes throughout the infection. The gene discussed is BIN1; the disease is infection.