Treatment of H460 cells with renieramycin M was found to stabilize p53 and decrease the levels of the anti-apoptotic proteins Mcl-1 and Bcl-2 [57], suggesting that this molecule is a promising anti-cancer drug candidate, particularly for lung cancer treatment since Bcl-2 is overexpressed in these cancer cells [57,58,59]. This evidence concerns the gene BCL2 and cancer.