Adenocarcinomas were identified in 21of 22 invasive carcinomas in p16−/−; LSL- KrasG12D; Pdx1-Cre mice and comprised ≥ 50% in 13 of the 21 invasive carcinomas (Fig. 2B-a, Table S1) and in 9 of 9 in p16flox/flox; LSL- KrasG12D; Pdx1-Cre mice and comprised ≥ 50% in 5 of the 9 in p16flox/flox; LSL- KrasG12D; Pdx1-Cre mice (Fig. S3f, Table S2). The gene discussed is PDX1; the disease is invasive carcinoma.