APP and Alzheimer disease: In the transgenic mouse AD model Tg2576 in which the human APP Swedish mutation is expressed under the control of a hamster prion promoter and is associated with plaques, dystrophic neurites, vascular involvement and gliosis, analyses of transcription showed up-regulation of ttr. TTR protein was immunochemically detected in neurons in the hippocampus and cerebral cortex, although neuronal-specific ttr transcripts were not assessed [171,197].