In contrast to the results suggesting a salutary effect of TTR in the Tg2576 AD model [171], other investigators reported that total and vascular Aβ burdens in pooled 13-20 month-old Tg2576/TTR-/- mouse brains were significantly increased compared to Tg2576/TTR+/- mice [199]. The gene discussed is TTR; the disease is Alzheimer disease.