Higher percentages of CD4/Foxp3 positive cells were found in spleens and LN from nontumor-bearing Pmel/Foxp3EGFP mice compared to C57BL/6 Foxp3EGFP mice (overall average 25% compared with 12%), but there was no additional Foxp3 enrichment among CD4 TIL in tumor-bearing animals. Here, FOXP3 is linked to neoplasm.