GM, geometric mean. aAll follow-up time points areadjusted for baseline ACTH values; the model was adjusted for age,education, social inhibition, negative affect, and depression (BDI-II)scores. bEstimates of the percent increase or decrease in ACTHassociated with an IQR increase in log-BPb or log-TPb are based on aregression model using log(ACTH) as a continuous response and log(BPb)or log(TPb) as a continuous predictor. This evidence concerns the gene POMC and major depressive disorder.