POMC and major depressive disorder: GM, geometric mean. aAll follow-up time points areadjusted for baseline ACTH:CORT ratio values; the model is adjusted forage, education, social inhibition, negative affect, and depression(BDI-II) scores. bEstimates of the percent increase or decreasein ACTH:CORT ratio associated with an IQR increase in log-BPb or log-TPbare based on a regression model using log(ACTH:CORT ratio) as acontinuous response and log(BPb) or log(TPb) as a continuouspredictor.