ITGA6 and neoplasm: As observed in univariate analyses, ITGA6 showed a time-dependent prognostic effect in both complete (HR 7.5, 95% CI 2.6 to 21.6, P < 0.001; T 0.18 95% CI 0.06 to 0.54, P = 0.002) and imputed (HR 2.8, 95% CI 1.2 to 6.3, P = 0.013; T 0.50, 95% CI 0.24 to 1.0, P = 0.055) datasets (CCA five-year BCSS adjusted for tumour size, grade and node status: ITGA6 negative = 87%; ITGA6 positive = 77%).