Finally, the two groups of breast cancer patients showed a completely different memory sharing among CD8+ cells, with a prevalence of naïve (P = 0.002) and CM cells (P = 0.005) in HER2- cases and higher percentages of EM (P = 0.005) and Temra cells (P = 0.012) in HER2+ patients. This evidence concerns the gene CD8A and breast carcinoma.