We have previously systematically investigated oncogenesis of T-ALL initiated by ICN1 overexpression in a bone marrow transplantation (BMT) model; we found that c-Myc is upregulated in nonmalignant ICN1-overexpressing cells as well as malignant ICN1-overexpressing cells at both of mRNA and protein levels [98]. Here, MYC is linked to acute lymphoblastic leukemia.