MAML1 and acute lymphoblastic leukemia: To identify novel pro-oncogenic pathways regulated by Notch, Chan et al. [122] used reverse phase protein (RPP) microarrays to profile the phosphorylation changes in a large number of signaling proteins in 13 T-ALL cell lines treated with GSI they found that the phosphorylation of multiple signaling proteins in the mTOR pathway was suppressed by inhibition of Notch signaling in a Notch-dependent manner, as this phenomenon can be rescued by expression of ICN1 and mimicked by dominant negative MAML1, suggesting that Notch signals positively regulate activity of the mTOR pathway in T-ALL.