CDK4 and acute lymphoblastic leukemia: To evaluate the mechanism by which Notch1 regulates cell-cycle progression in T-ALL, experiments from Joshi group [114] show that cyclin D3 functions together with its catalytic partners CDK4 and CDK6 to facilitate cell cycle progression in Notch1-dependent T-cell lymphoma, because Notch1 binds directly to the region of −1764 bp to −1537 bp of cyclin D3 promoter and specifically regulates cyclin D3 promoter activity revealed by ChIP analysis and luciferase reporter assay.