PGGT1B and Familial prostate cancer: The purpose of this study was to confirm the anti-cancer activity of zoledronic acid (Zol), one of the most potent bisphosphonates, in androgen-sensitive and -independent prostate cancer cells and evaluate the potential of geranylgeranyltransferase inhibitor (GGTI) with or without docetaxel as a treatment option for advanced prostate cancer.