Additionally, blockade of AR pathways attenuates FKBP5 expression, which is androgen dependent in prostate cancer cells, resulting in increased AKT phosphorylation due to a reduction in PHLPP protein levels since FKBP5 is a molecular chaperone for the AKT phosphatase PHLPP. The gene discussed is PHLPP1; the disease is Familial prostate cancer.