After adjusting for potential confounders, including baseline Hb level, a decline in Hb after 3 months of ADT was associated independently with shorter survival (hazards ratio [HR], 1.10 per 1 g/dL decline; P = 0.0035) and shorter progression-free survival (HR, 1.08 per 1 g/dL decline; P = 0.013) [67] In another study, after a period of 2.5 years on ADT, four patients out of twenty-four were found to be affected by coronary heart disease. This evidence concerns the gene GSTM1 and coronary artery disorder.