CD8A and mitochondrial DNA depletion syndrome 4a: To identify possible factors associated with AHD, significant T-cells immune phenotypes in the univariate analysis (CD8+%, CD4+CD127+%, CD8+CD95+%, CD8+CD38+%, and CD8+CD38+CD45R0+%) (Table 3(b)) were entered in a logistic regression model, mutually adjusted for age and risk group (Table 5).