Comparing immune phenotypes between AIDS presenters and N-AIDS presenters, we observed that AIDS presenters were associated with lower CD4+ T-cell count (median CD4+ cells/μL: AIDS presenters 132, IQR 60–286—N-AIDS presenters 438, IQR 286–583; P = 0.0001), and higher CD8+ T cells (median CD8+%: AIDS presenters 59, IQR 50–66—N-AIDS presenters 49, IQR 42–59; P = 0.0001). The gene discussed is CD8A; the disease is AIDS.