RARA and acute promyelocytic leukemia: Geographical variations in frequency and clinical characteristics of hematological malignancies in patients from Europe/US and those from Latin America have been described in lymphoid malignancies,1–4 and to a lesser extend in myeloid neoplasms.5–8 Acute Promyelocytic Leukemia (APL) is a distinct type of myeloid leukemia characterized by its invariable association with chromosomal translocations involving the Retinoid Acid Receptor α(RARA) gene in chromosome 17.