Likewise, the breakpoints in the Promyelocytic Leukemia (PML) gene, the main partner of RARA in APL-associated rearrangements, are clustered in three regions: one in exon 3 originating the short form type of PML-RARA fusion gene, or bcr3, and two in exon 6: the long form, or bcr1 and the variable form, or bcr2.9 Due to the fact that the PML-RARA is detected in more than 98% of patients with APL, the disease is a paradigm of acute myeloid leukemia (AML) associated with recurrent chromosomal translocations. The gene discussed is PML; the disease is acute myeloid leukemia.