We cloned the NS1 protein from two seasonal H3N2 human influenza isolates of the 2007 epidemic (VR9220 and VR9240), bearing an intact SHB domain 1, but with one aminoacid substitution in a conserved Pro of SHB domain 2 (-PPØTPK-), an compared them to the F3 and H5N1 NS1 protein for their ability to stimulate Src. The gene discussed is SRC; the disease is influenza.