IFIH1 and type 1 diabetes mellitus: Recently, deep sequencing of exons and splice sites in the IFIH1 gene revealed that lower risk of type 1 diabetes is also associated with two rare variants with a presumed loss of function (nonsynonymous SNPs rs35744605 (E627X) and rs35667974 (I923V)), and with two noncoding variants affecting conserved splice sites (rs35337543 (1641+1G>C)) and rs35732034 (2807+1G>A)), odds ratios of about 0.5–0.7 [20].