CCN3 and melanoma: Several other positive modulators of chondrogenesis or constituents of cartilage ECM were also downregulated including Type IX collagens, Mia/Cd-rap (melanoma inhibitory activity or cartilage-derived retinoic acid sensitive protein), Nov/Ccn3 (nephroblastoma overexpressed protein), Crtl1/Hapln1 (cartilage link protein/hyaluronic acid proteoglycan linking protein 1), Matn3 (Matrillin 3), Clip2 (cartilage intermediate layer protein 2) and Lect1/Chm-1 (leukocyte cell derived chemotaxin 1 or chondromodulin-1) (Figure 4C).