In this study, the expression of both MMP2 and TIMP2 increased during LX-2 activation induced by TGF-β1; however, after AdNDRG2 infection, MMP2 was enhanced while TIMP2 levels decreased (Figure 3C) compared with AdLacZ controls (MMP9 and TIMP1 were undetectable). This evidence concerns the gene MMP2 and infection.