MAGEC1 and plasma cell myeloma: Prompted by the hypothesis that the MAGE-C1/CT7 gene could have an important biological role in MM tumorigenesis, we planned: (1) to identify MM cell lines with MAGEC1/CT7 expression, (2) to obtain a stable and efficient silencing of MAGE-C1/CT7 gene by small hairpin RNA (shRNA) in a MAGE-C1/CT7-positive myeloma cell line to perform functional studies, and (3) to evaluate the impact of silencing MAGE-C1/CT7 on cells treated with novel proteasome inhibitor anti-myeloma agent bortezomib.