P53 is the most mutated protein in human cancers,[1] and mutations of p53 alone account for more than half of invasive types of cancer.[2] According to the latest version (R15) of the TP53 mutation database,[3] 27 580 different somatic mutations have been identified in the full-length protein and the overwhelming majority of alterations are located within the core DNA-binding domain (DBD). This evidence concerns the gene TP53 and cancer.