Fungus-stimulated MDDCs significantly enhanced the capacity to mediate HIV-luc/JRFL or HIV-luc/NL4-3 trans infection of HutCCR5 cells, there was a 4.8- to 6.5-fold increase in luciferase activity (Figure 3B), when activated primary CD4+ T cells were used as target, fungus-stimulated MDDCs enhanced HIV-luc/NL4-3 trans-infection of primary CD4+ T cells approximately 2-3- fold (Figure 3C). Here, CD4 is linked to infection.