As summarized in Table 6, at the early stage I phase of MM, simulated RANKL and IL-6 concentration increase about 1.75-fold and 3.55-fold respectively, while clinical observations indicate that RANKL and IL-6 concentration increase about 1.62-fold and 2.6-fold respectively [70], [75]. The gene discussed is TNFSF11; the disease is Miyoshi myopathy.