The observed major clinical features of MM disease include: the increased bone resorption markers (i.e., N-terminal telopeptides of type I collagen, NTX) and bone formation marker (i.e., bone-specific alkaline phosphotase, bALP) [66], indicating an increase in the number of osteoclasts and osteoblasts as a result of increased RANKL and decreased OPG concentrations. This evidence concerns the gene TNFSF11 and Miyoshi myopathy.