The qualitative and quantitative comparison of dynamic simulations with features of the MM disease progression (i.e., increase in the density of bone cells, in the density of MM cells, and in the concentrations of IL-6 and receptor activator of nuclear factor-κB ligand (RANKL), together with decrease in the concentration of osteoprotegerin (OPG), and decrease in the bone volume) shows that the proposed computational model appropriately reflects MM disease progression. Here, TNFRSF11B is linked to Miyoshi myopathy.