After 3-month treatment, HMG-CoA reductase activity in APS group, Simvastatin group and control group were 36.24±5.62 pmole/min/mg protein, 12.60±2.03 pmole/min/mg protein and 22.86±6.45 pmole/min/mg protein, respectively. Here, HMGCR is linked to autoimmune polyendocrinopathy.